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Original Articles
- Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
- Young Sim Choi, Han Byul Jang, Ju Yeon Park, Hye-Ja Lee, Jae-Heon Kang, Kyung-Hee Park, Jong Ho Lee, Sang Ick Park, Jihyun Song
- Osong Public Health Res Perspect. 2014;5(5):251-257. Published online October 31, 2014
- DOI: https://doi.org/10.1016/j.phrp.2014.08.008
- 3,114 View
- 16 Download
- 8 Crossref
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Abstract
PDF - Objectives
Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders.
Methods
Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5 ± 0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85th percentile for age and gender, based on Korean child growth standards.
Results
Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up.
Conclusion
In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia. -
Citations
Citations to this article as recorded by
- Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children
Man-Chin Hua, Hui-Min Su, Ming-Wei Lai, Tsung-Chieh Yao, Ming-Han Tsai, Sui-Ling Liao, Shen-Hao Lai, Jing-Long Huang
Frontiers in Pediatrics.2021;[Epub] CrossRef - Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?
Camila O. de Souza, Gretchen K. Vannice, José C. Rosa Neto, Philip C. Calder
Molecular Nutrition & Food Research.2018;[Epub] CrossRef - Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children
Lori M. Beccarelli, Rachel Erin Scherr, John W. Newman, Alison G. Borkowska, Ira J. Gray, Jessica D. Linnell, Carl L. Keen, Heather M. Young
Journal of the American College of Nutrition.2018; 37(1): 44. CrossRef - Continuous cardiometabolic risk score definitions in early childhood: a scoping review
M. Kamel, B. T. Smith, G. Wahi, S. Carsley, C. S. Birken, L. N. Anderson
Obesity Reviews.2018; 19(12): 1688. CrossRef - FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome
Ye Tian, Wei Zhang, Shigang Zhao, Yinhua Sun, Yuehong Bian, Tailai Chen, Yanzhi Du, Jiangtao Zhang, Zhao Wang, Tao Huang, Yingqian Peng, Ping Yang, Han Zhao, Zi-Jiang Chen
Scientific Reports.2016;[Epub] CrossRef - Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children
A. Viitasalo, J. Ågren, T. Venäläinen, J. Pihlajamäki, J. Jääskeläinen, A. Korkmaz, M. Atalay, T. A. Lakka
Pediatric Obesity.2016; 11(4): 299. CrossRef - Linoleic acid and the pathogenesis of obesity
Shaan S. Naughton, Michael L. Mathai, Deanne H. Hryciw, Andrew J. McAinch
Prostaglandins & Other Lipid Mediators.2016; 125: 90. CrossRef - Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats
Venkatesh Gopalan, Navin Michael, Seigo Ishino, Swee Shean Lee, Adonsia Yating Yang, K. N. Bhanu Prakash, Jadegoud Yaligar, Suresh Anand Sadananthan, Manami Kaneko, Zhihong Zhou, Yoshinori Satomi, Megumi Hirayama, Hidenori Kamiguchi, Bin Zhu, Takashi Hori
Scientific Reports.2016;[Epub] CrossRef
- Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children
- Relationship between Serum Levels of Body Iron Parameters and Insulin Resistance and Metabolic Syndrome in Korean Children
- Hye-Ja Lee, Han Byul Jang, Ji Eun Park, Kyung-Hee Park, Jae Heon Kang, Sang Ick Park, Jihyun Song
- Osong Public Health Res Perspect. 2014;5(4):204-210. Published online August 31, 2014
- DOI: https://doi.org/10.1016/j.phrp.2014.06.005
- 2,812 View
- 23 Download
- 16 Crossref
-
Abstract
PDF
- Objectives
An increase in serum ferritin and levels of the cleaved soluble form of transferrin receptor (sTfR) are related to several metabolic conditions. We evaluated the relationship between body iron status indicators, including ferritin and sTfR, and insulin resistance and metabolic syndrome (MetS) in Korean children.
Methods
A cross-sectional study was conducted on 1350 children in Korea. Anthropometrical parameters; lipid profiles; levels of glucose, insulin, and leptin; and iron status indicators, including sTfR, serum ferritin, serum iron, total iron-binding capacity (TIBC), and transferrin saturation (TS), were analyzed.
Results
Although serum sTfR levels were significantly higher in boys than in girls (2.20 vs. 2.06 mg/L, p < 0.0001), serum iron and TS were higher in girls than in boys (101.38 vs. 95.77 mg/L, p = 0.027 and 30.15 vs. 28.91%, p = 0.04, respectively). Waist circumference (WC) and leptin were most significantly associated with body iron indicators when adjusted for age and sex. After adjusting for age, sex, and WC, sTfR levels showed the strongest positive association with leptin levels (p = 0.0001). Children in the highest tertile for homeostasis model assessment-insulin resistance (HOMA-IR) had higher TIBC (p = 0.0005) and lower serum iron (p = 0.0341), and the lowest TS (p < 0.0001) after adjustment for confounders. Children with higher sTfR were most significantly associated with risk of MetS compared with those lower sTfR (p = 0.0077).
Conclusion
The associations of serum levels of iron metabolism markers with leptin levels, HOMA-IR, and MetS suggest that iron-related factors may involve insulin resistance and MetS. -
Citations
Citations to this article as recorded by- Relationship between trajectories of dietary iron intake and risk of type 2 diabetes mellitus: evidence from a prospective cohort study
Ruoting Wang, Yingxin Liu, Lehana Thabane, Ivan Olier, Likang Li, Sandra Ortega-Martorell, Gregory Y.H. Lip, Guowei Li
Nutrition Journal.2024;[Epub] CrossRef - Serum iron concentration and leptin inversely relate, partially mediated by body mass index in American adults
Mi Chen, Yuebai Chen, Chao Li
Nutrition Research.2024; 124: 1. CrossRef - Association between serum ferritin level and lipid profile among diabetic patients: A retrospective cohort study
Saif Aboud M Alqahtani, Mohammed Abadi Alsaleem, Ramy Mohamed Ghazy
Medicine.2024; 103(13): e37631. CrossRef - Relationship between Serum Ferritin Level and Dyslipidemia in US Adults Based on Data from the National Health and Nutrition Examination Surveys 2017 to 2020
Guohua Li, Wenlu Yu, Hexiang Yang, Xinyue Wang, Tianyou Ma, Xiaoqin Luo
Nutrients.2023; 15(8): 1878. CrossRef - Iron status and cardiometabolic risk in children
Milton Fabian Suárez-Ortegón, Anna Prats-Puig, Judit Bassols, Gemma Carreras-Badosa, Stela McLachlan, Sarah H. Wild, Abel López-Bermejo, Jose Manuel Fernández-Real
Diabetes Research and Clinical Practice.2023; 202: 110795. CrossRef - Association between biomarkers of iron status and cardiometabolic risk in Spanish children aged 9–10 years. The ELOIN study
Honorato Ortiz-Marrón, Gloria Cabañas Pujadas, Encarnación Donoso Navarro, Mar Burreros García, María Isabel Herreros Álvaro, Alma María Mejía Fernández de Velasco, Ana Cornejo Gutiérrez, Iñaki Galán
European Journal of Pediatrics.2023; 182(12): 5649. CrossRef - Serum ferritin levels among schoolchildren and its correlation with lipid profile and adiposity
Mariana Orta-Duarte, Rosa del Carmen Vázquez-Zapien, Hugo Ventura-Cisneros, Mario del Toro-Equihua, Benjamin Trujillo-Hernández, Carmen Alicia Sánchez-Ramírez
Archivos Latinoamericanos de Nutrición.2021; 70(3): 155. CrossRef - Ferritin levels throughout childhood and metabolic syndrome in adolescent stage
M.F. Suárez-Ortegón, E. Blanco, S. McLachlan, J.M. Fernandez-Real, R. Burrows, S.H. Wild, B. Lozoff, S. Gahagan
Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(3): 268. CrossRef - The immune-nutrition interplay in aging – facts and controversies
Iftikhar Alam, Ali M. Almajwal, Wajid Alam, Ibrar Alam, Niamat Ullah, Mahmoud Abulmeaaty, Suhail Razak, Saleem Khan, Graham Pawelec, Parvez Iqbal Paracha
Nutrition and Healthy Aging.2019; 5(2): 73. CrossRef - Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study
Yanna Zhu, Baoting He, Yunjun Xiao, Yajun Chen
Lipids in Health and Disease.2019;[Epub] CrossRef - Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model
Vladimir Jakoviljevic, Petar Milic, Jovana Bradic, Jovana Jeremic, Vladimir Zivkovic, Ivan Srejovic, Tamara Nikolic Turnic, Isidora Milosavljevic, Nevena Jeremic, Sergey Bolevich, Milica Labudovic Borovic, Miroslav Mitrovic, Vesna Vucic
International Journal of Molecular Sciences.2018; 20(1): 6. CrossRef - High-fat diet–induced plasma protein and liver changes in obese rats can be attenuated by melatonin supplementation
Prapimpun Wongchitrat, Paul Klosen, Supitcha Pannengpetch, Kuntida Kitidee, Piyarat Govitrapong, Chartchalerm Isarankura-Na-Ayudhya
Nutrition Research.2017; 42: 51. CrossRef - Relationship between Serum Ferritin Levels and Dyslipidemia in Korean Adolescents
Young-Eun Kim, Do-Hoon Kim, Yong-Kyun Roh, Sang-Yhun Ju, Yeo-Joon Yoon, Ga-Eun Nam, Hyo-Yun Nam, Jun-Seok Choi, Jong-Eun Lee, Jung-Eun Sang, Kyungdo Han, Yong-Gyu Park, David O. Carpenter
PLOS ONE.2016; 11(4): e0153167. CrossRef - Investigation of the relationship between hemoglobin and serum iron levels and early-phase insulin secretion in non-diabetic subjects
Masanori Shimodaira, Shinji Okaniwa, Tomohiro Nakayama
Acta Diabetologica.2016; 53(5): 783. CrossRef - Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case–control study
Y.N. Zhu, B.T. He, J. Jing, J. Ma, X.H. Li, W.H. Yang, Y. Jin, Y.J. Chen
Nutrition, Metabolism and Cardiovascular Diseases.2016; 26(6): 525. CrossRef - Biomarkers of iron metabolism are independently associated with impaired glucose metabolism and type 2 diabetes: the KORA F4 study
Cornelia Huth, Simon Beuerle, Astrid Zierer, Margit Heier, Christian Herder, Thorsten Kaiser, Wolfgang Koenig, Florian Kronenberg, Konrad Oexle, Wolfgang Rathmann, Michael Roden, Sigrid Schwab, Jochen Seissler, Doris Stöckl, Christa Meisinger, Annette Pet
European Journal of Endocrinology.2015; 173(5): 643. CrossRef
- Relationship between trajectories of dietary iron intake and risk of type 2 diabetes mellitus: evidence from a prospective cohort study
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